what are we doing?

      Our Approach

      Thanks to our expertise in targeted protein degradation we take a multi-faceted approach to eliminate pathological proteins. Our technology consists of bifunctional molecules and direct degraders.

      Our proprietary Obteron™ platform enables the robust discovery of therapeutic compounds with good biopharmaceutical properties. These compounds lead to efficient protein degradation via proteasome and/or autophagosome.

      Supported by over 44 mln EUR from European grants and private investors, we are currently working on projects aiming at (1) advancement of a protein degradation platform and (2) development of first-in-class therapeutics for autoimmune and oncological indications.

      At Captor Therapeutics we cover all aspects of early-stage drug development to deliver therapeutics for life-threatening and life-impairing diseases.

      Our integrated approach combines in-house organic and medicinal chemistry with molecular modelling, high-throughput phenotypic screenings, biophysics and in vitro degradation assays.

      To unlock the potential of UPS (Ubiquitin Proteasome System) Captor Therapeutics is developing a large platform of ubiquitin ligases with their ligands. This approach will enable us to adapt the degradation process to therapeutic indication.

      Pipeline

      Our main goal is silencing of disfunctional proteins on the post-translational level. To this end we are using a broad spectrum of chemical biology methods. Currently, we are developing first-in-class molecules to treat various pathological conditions, e.g. cancer and autoimmune diseases.

      Today, biologics (antibodies or their fragments) represent the main therapeutic modality for the treatment of many of the  autoimmune and inflammatory conditions. Many of these biologics control the pathogenic process by interjecting with either surface receptor proteins or their extracellular ligands. The main disadvantage of this approach is that pathogenic proteins often play roles in more than one downstream signaling processes. Inhibition of these receptors by antibodies dysregulates pathogenic but also beneficial molecular pathways, which ultimately leads to severe side effects of targeted therapies. In Captor Therapeutics, through our proprietary protein degradation platform, we selectively target only downstream pathogenic signaling activated by the aforementioned receptors, while preserving the beneficial pathways. This approach is used to intervene in autoimmune, inflammatory and neurodegenerative diseases.

      Spontaneous mutations often abrogate interactions between E3 ubiquitin ligases and their partner proteins. This may result in accumulation of the latter, leading to dysregulation of molecular signalling and ultimately to tumorigenesis. Captor Therapeutics has developed a molecular repair platform that is capable of reconstituting interactions between ubiquitin ligases and their molecular partners, which restores cellular homeostasis and prevents cancer progression.

      Grant Projects

      Grant projects co-funded by the National

      Centre for Research and Development:

      • Elaboration of interaction assays suitable for screening of the chemical compounds used in a first-in-class drug development (POIR.04.01.02-00-0147/16-00).

        Project carried out within the Measure 4.1 "Research and development", Sub-measure 4.1.4  "Regional research agendas" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund

        Project is realized by Consortium comprising: Institute of Immunology and Experimental Therapy Polish Academy of Sciences in Wroclaw, Captor Therapeutics Inc

        Value of the project: 4 314 375.00 PLN
        European Union financing: 3 834 558.00 PLN

        Goal and expected results of the project: development of scalable and sensitive high-throughput fluorescence assay allowing for rapid detection of active PROTAC compounds which induce degradation of pathological proteins.

      • Development and implementation of an innovative platform for the identification drug-like compounds (POIR.04.01.04-00-0116/16-00).

        Project carried out within the Measure 4.1 "Research and development", Sub-measure 4.1.1  "Application projects" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund

        Project realized by Consortium comprising: The National Centre of Research and Development Ltd, Captor Therapeutics Inc

        Value of the project: 4 968 788.76 PLN
        European Union financing: 4 260 002.76 PLN

        Goal and expected results:  development of two-stage high-throughput screening assay for low molecular weight compounds which induce targeted protein degradation.

      • Development of first-in-class anti-inflammatory drugs specifically degrading disease modifying proteins (POIR.01.01.01-00-0747/16-00).

        Project carried out within the Measure 1.1 "R&D projects of enterprises", Sub-measure 1.1.1  "Industrial research and development work implemented by enterprises" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund

        Value of the project: 32 164 999.43 PLN
        European Union financing: 24 460 751.26 PLN
         
        Goal and expected results: Development low molecular weight compunds inhibiting receptor proteins by applying the bispecific inductor degradation (BID) technology which will be drug candidates for patients ailed with rheumathoid arthritis or inflammatory bowel disease.
      • Small molecules as therapeutic intervention in multiple severe malignancies (POIR.01.01.01-00-0956/17-00).

        Project carried out within the Measure 1.1 "R&D projects of enterprises", Sub-measure 1.1.1  "Industrial research and developmend work implemented by enterprises" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund   

        Value of project: 35 902 013.75 PLN
        European Union financing: 27 683 098.00 PLN

        Goal and expected results of the project: Development and testing in the first stage of clinical tests of low molecular weight chemical compounds which will be future drug candidates in tumor therapies of  non-small lung cancer and triple negative breast cancer.

      • Application of targeted protein degradation technology in the treatment of psoriasis and rheumatoid arthritis (POIR.01.02.00-00-0079/18).

        Project carried out within the Priority Axis I: Supporting R&D carried out by enterprises”, Measure 1.2 „Sectoral R&D programmes”, as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund

        Value of project: 37 130 943.75 PLN
        European Union financing: 29 558 070.00 PLN

        Goal and expected results of the project: Discovery and development novel, first in class oral drugs targeting key drivers of rheumatoid arthritis, psoriasis and ulcerative colitis.

      • Discovery and Development of First-in-Class of Small Molecule Degrader As a Drug Candidate For the Treatment of Colorectal Cancer (POIR.01.02.00-00-0073/18).

        Project carried out within the Priority Axis I: Supporting R&D carried out by enterprises”, Measure 1.2 „Sectoral R&D programmes”, as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund

        Value of project: 32 041 906.25 PLN
        European Union financing: 25 510 680.00 PLN

        Goal and expected results of the project: Development of first, oral targeted therapy focused on interruption of the main cause of colorectal cancer (CRC). The efficacy and bioavailability of the drug candidate will be tested in preclinical phase, followed by the Phase I clinical trials.

      • Development of targeted oncogenic transcription factor degradation technology in the treatment of hepatocellular carcinoma (POIR.01.01.01-00-0740/19).

        Project carried out within the Measure 1.1 "R&D projects of enterprises", Sub-measure 1.1.1  "Industrial research and development work implemented by enterprises" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund.

        Value of the project: 36 389 016.25 PLN
        European Union financing: 28 959 643.00 PLN

        Goal of project: Development of a drug candidate in the treatment of hepatocellular carcinoma that allows the elimination of cancer cells through induced degradation of oncogenic transcription factor. The efficacy and bioavailability of the drug candidate will be tested in preclinical phase, followed by the Phase I clinical trials.

      • Development of technological platform in the area of targeted protein degradation and its implementation on the pharmaceutical market (POIR.01.01.01-00-0931/19).

        Project carried out within the Measure 1.1 "R&D projects of enterprises", Sub-measure 1.1.1  "Industrial research and development work implemented by enterprises" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund.

        Value of the project: 10 135 628.75 PLN
        European Union financing: 7 759 469.50 PLN

        Goal and expected results of the project: Development and implementation of technological platform through generation of modular small molecules capable of inducing protein degradation upon recruitment of novel ubiquitin ligases.

      • Development of non-toxic ligase ligands and their application in the treatment of autoimmune diseases (POIR.01.01.01-00-0741/19).

        Project carried out within the Measure 1.1 "R&D projects of enterprises", Sub-measure 1.1.1  "Industrial research and development work implementet by enterprises" as part of the Operational Programme Smart Growth 2014-2020 co-funded by the European Regional Development Fund.

        Value of the project: 34 441 900.00  PLN
        European Union financing: 27 411 400.00 PLN

        Goal and expected results of the project: Development of a drug candidate in the treatment of autoimmune diseases through generation of non-toxic ligase ligands. The efficacy and bioavailability of the drug candidate will be tested in preclinical phase, followed by the Phase I clinical trials.

      Technology

      Degradation of proteins is a relatively new approach in drug development. We are developing low molecular weight compounds capable of inducing degradation of targeted proteins in vivo. These compounds can be further developed into new therapeutics with limited side effects and convenient routes of administration. One of the most substantial features of our drug candidates is the fact that their efficiency is not dependent on the enzymatic or binding function of the protein of interest, therefore we are also able to target the so-called “undruggable” proteome.

      Captor Therapeutics' drug discovery platform is based on an array of chemical biology tools that hijacks intracellular protein degradation machinery. Our expertise covers also allosteric modulation of proteins (allostery platform), fragment-based drug discovery (FBDD), structure-based drug design (SBDD) and phenotypic screenings.

      The company’s mode of action is presented on the scheme – we communicate with doctors and patients to identify areas which suffer from an urging need for novel therapeutics (for example due to substantial side effects of known drugs, their limited effectiveness, or no drugs being available at all). Then, using our proprietary screening platform and a tailored library of chemical structures developed by our chemists and biochemists we identify possible drug candidates towards selected disease-related molecular targets (proteins of interest). After collecting the initial research data and confirming the desired activity of the future drug we move first to pre-clinical, and then to clinical trials. At this point a close partnership between researchers, clinicians and patients is required to gather large amounts of significant and conclusive data which enable us to bring the new therapeutic to the market.